Smoking Cessation

Smokers and Non-smokers, 21-65 years old are invited to participate in a research study. The purpose of this research study is to find if smoking cessation combined with Sildenafil will decrease inflammation in the lungs of smokers. We will also be comparing lung imaging and the effects of Sildenafil of smokers with that of non-smokers.
Sildenafil is an FDA approved medication that is approved for many different uses including the treatment of pulmonary hypertension, but it will be given during this study, in a non-FDA-approved manner.

SOURCE

SOURCE is a research study to understand the lung’s response to tobacco smoke exposure. People who smoke can develop changes in their airways and lungs long before they have symptoms that are often linked to COPD, like cough or shortness of breath. Because most studies of COPD have enrolled older individuals, this study will help us better understand the early stages of COPD in younger people. The SOURCE research study is taking place at 14 sites across the United States.