Our group has worked on the optimization of CT imaging protocols and/or validation of quantitative CT biomarkers for the assessment of lung structure. The focus to date has been on assessment of low and ultra-low dose radiation levels on quantitative lung structure assessment. Ongoing work is focused on new CT scanner technology (photon counting)

_{E. Hammond, C. Sloan, J.D. Newell, J.P. Sieren, M. Saylor, C. Vidal, S. Hogue, F. De Stefano, A. Sieren, E.A. Hoffman, J.C. Sieren, ‘Comparison of Low and Ultra-Low Dose Computed Tomography Protocols for Quantitative Lung and Airway Assessment’, Medical Physics 44(9):4747-4757 (2017) PMC5603212}

_{E. Hammond, KS Chan, J.C. Ames, N. Stoyles, C.M. Sloan, J. Guo, J.D. Newell, E.A. Hoffman, J.C. Sieren ‘Impact of Advanced Detector Technology and Iterative Reconstruction on Low Dose Quantitative Assessment of Lung Computed Tomography Density in a Biological Lung Model, Medical Physics.45(8):3657-3670 (2018) PMC3009498}

_{Shankar SS, Hoffman EA, Atha J, Sieren JC, Samei E, Abadi E. Inter- and intra-scan variability for lung imaging quantifications via CT. Proc SPIE Int Soc Opt Eng. 2022 Feb-Mar;12031:120312C. doi: 10.1117/12.2613191. Epub 2022 Apr 4. PMID: 35547179; PMCID: PMC9087481.}