We have optimized longitudinal medical imaging studies for characterizing novel large animal models of human disease. These models present unique advantages for technology and technique development in the areas of image acquisition, surgery, pharmaceutical delivery and longitudinal disease monitoring, due to the similarity in size, metabolism etc. with human patients.

_{J.C. Sieren^*, D.K. Meyerholz^*, X. Wang, B. Davis, J. D. Newell, E. Hammond, J. Rohret, F. Rohret, J. Struzynski, J.A. Goeken, P.W. Naumann, M.R. Leidinger, J. Hagen, R. VanRheeden, B.W. Darbro, D.E. Quelle, C.S. Rogers, “Translational imaging of tumorigenesis in a TP53 porcine cancer model”, Journal of Clinical Investigation, 124(9): 4052-66 (2014) PMC4151205 *Co-first authors}

_{D. K. Meyerholz, J.C. Sieren, A. Beck, H. A. Flaherty, ‘Approaches to evaluate lung inflammation in translational research’ Veterinary Pathology 55(1):42-52 (2017) PMC5600706}

_{KA White., VJ Swier, JT Cain, JL Kohlmeyer,  D.K. Meyerholz, M.R  Tanas, J. Uthoff, E. Hammond, H. Li, F.A  Rohret, A Goeken, CC Chan, MR Leidinger, S Umesalma, M.R. Wallace, R.D. Dodd, K. Panzer, AH Tang, B.W  Darbro, A Moutal, S Cai, W. Li, SS Bellampalli, R. Khanna, C.S Rogers*, J.C. Sieren*, D.E Quelle*, and J.M Weimer* A porcine model of Neurofibromatosis Type 1 (NF1) that mimics the human disease. JCI Insights 3(12):e120402 (2018). PMC6124439 *Co-communicating authors}

_{Swier VJ, White KA, Johnson TB, Sieren JC, Johnson HJ, Knoernschild K, Wang X, Rohret FA, Rogers CS, Pearce DA, Brudvig JJ, Weimer JM. A novel porcine model of CLN2 Batten disease that recapitulates patient phenotypes. Neurotherapeutics 2022 Oct;19(6):1905-1919. doi: 10.1007/s13311-022-01296-7. Epub 2022 Sep 13. PMID: 36100791; PMCID: PMC9723024.}