Our group has worked on the optimization of CT imaging protocols and/or validation of quantitative CT biomarkers for the assessment of lung structure. The focus to date has been on assessment of low and ultra-low dose radiation levels on quantitative lung structure assessment. Ongoing work is focused on new photon counting detector CT (PCD-CT) scanner technology.

^{Sieren JC, Schroeder KE, Kitzmann J, Knoernschild K, Atha J, AlArab N, Guo J, Fain SB, Hoffman EA. Ultra-High Resolution Photon Counting Detector Computed Tomography Imaging for Quantitative Lung Assessment -An Anthropomorphic Phantom Study. Investigative Radiology 2025 (In Press)}

^{Shankar SS, Felice N, Hoffman EA, Atha J, Sieren JC, Samei E, Abadi E. Task‐based validation and application of a scanner‐specific CT simulator using an anthropomorphic phantom. Medical Physics. 2022 Dec;49(12):7447-7457. doi: 10.1002/mp.15967. Epub 2022 Nov 12. PMID: 36097259; PMCID: PMC9792443.}

^{E. Hammond, C. Sloan, J.D. Newell, J.P. Sieren, M. Saylor, C. Vidal, S. Hogue, F. De Stefano, A. Sieren, E.A. Hoffman, J.C. Sieren, ‘Comparison of Low and Ultra-Low Dose Computed Tomography Protocols for Quantitative Lung and Airway Assessment’, Medical Physics 44(9):4747-4757 (2017) PMC5603212 doi:10.1002/mp.12436}

^{E. Hammond, KS Chan, J.C. Ames, N. Stoyles, C.M. Sloan, J. Guo, J.D. Newell, E.A. Hoffman, J.C. Sieren ‘Impact of Advanced Detector Technology and Iterative Reconstruction on Low Dose Quantitative Assessment of Lung Computed Tomography Density in a Biological Lung Model, Medical Physics.45(8):3657-3670 (2018) PMC3009498 doi: 10.1002/mp.13057.}