We have optimized longitudinal medical imaging studies for characterizing novel large animal models of human disease. These models present unique advantages for technology and technique development in the areas of image acquisition, surgery, pharmaceutical delivery and longitudinal disease monitoring, due to the similarity in size, metabolism etc. with human patients.

^{Knoernschild K, Johnson HJ, Schroeder KE, Swier VJ, White KA, Sato TS, Rogers CS, Weimer JM, Sieren JC. Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model. Sci Rep. 2023 Mar 29;13(1):5146. doi: 10.1038/s41598-023-32071-z. PMID: 36991106; PMCID: PMC10060411}

^{Bruz M, Knoernschild K, Sieren JC, Johnson HJ. PigSNIPE: Scalable Neuroimaging Processing Engine for Minipig MRI. Algorithms 2023, 16, 116. https://doi.org/10.3390/a16020116}

^{Sieren JC*, Meyerholz DK*, Wang XJ, Davis BT, Newell JD, Jr., Hammond E, Rohret JA, Rohret FA, Struzynski JT, Goeken JA, Naumann PW, Leidinger MR, Taghiyev A, Van Rheeden R, Hagen J, Darbro BW, Quelle DE, Rogers CS. Development and translational imaging of a TP53 porcine tumorigenesis model. The Journal of clinical investigation. 2014;124(9):4052-66. Epub 2014/08/12. doi: 10.1172/jci75447. PubMed PMID: 25105366; PMCID: PMC4151205. (*contributed equally)}

^{Meyerholz DK, Sieren JC, Beck AP, Flaherty HA. Approaches to Evaluate Lung Inflammation in Translational Research. Veterinary pathology. 2018;55(1):42-52. Epub 2017/08/16. doi: 10.1177/0300985817726117. PubMed PMID: 28812529; PMCID: PMC5600706.}

^{White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, Dodd RD, Panzer K, Tang AH, Darbro BW, Moutal A, Cai S, Li W, Bellampalli SS, Khanna R, Rogers CS*, Sieren JC*, Quelle DE*, Weimer JM*. A porcine model of neurofibromatosis type 1 that mimics the human disease. JCI Insight. 2018;3(12):e120402. Epub 2018/06/22. doi: 10.1172/jci.insight.120402. PubMed PMID: 29925695; PMCID: PMC6124439. (*contributed equally)}

^{Swier VJ, White KA, Johnson TB, Sieren JC, Johnson HJ, Knoernschild K, Wang X, Rohret FA, Rogers CS, Pearce DA, Brudvig JJ, Weimer JM. A novel porcine model of CLN2 Batten disease that recapitulates patient phenotypes. Neurotherapeutics 2022 Oct;19(6):1905-1919. doi: 10.1007/s13311-022-01296-7. Epub 2022 Sep 13. PMID: 36100791; PMCID: PMC9723024.}